Flow-vegetation interactions at the plant-scale: the importance of volumetric canopy morphology on flow field dynamics

Vegetation is abundant in rivers, and has a significant influence on their hydraulic, geomorphological, and ecological functioning. However, past modelling of the influence of vegetation has generally neglected the complexity of natural plants. This thesis develops a novel numerical representation of flow through and around floodplain and riparian vegetation, focusing on flow-vegetation interactions at the plant-scale. The plant volumetric canopy morphology, which comprises the distribution of vegetal elements over the three-dimensional plant structure, is accurately captured at the millimetre scale spatial resolution using Terrestrial Laser Scanning (TLS), and incorporated into a Computational Fluid Dynamics (CFD) model used to predict flow. Numerical modelling, with vegetation conceptualised as a porous blockage, is used to improve the process-understanding of flow-vegetation interactions. Model predictions are validated against flume experiments, with plant motion dynamics investigated, and analysis extended to consider turbulent flow structures and the plant drag response. Results demonstrate the spatially heterogeneous velocity fields associated with plant volumetric canopy morphology. The presence of leaves, in addition to the posture and aspect of the plant, significantly modifies flow field dynamics. New insights into flow-vegetation interactions include the control of plant porosity, influencing ‘bleed-flow’ through the plant body. As the porosity of the plant reduces, and bleed-flow is prevented, the volume of flow acceleration increases by up to ~150%, with more sub-canopy flow diverted beneath the impermeable plant blockage. Species-dependent drag coefficients are quantified; these are shown to be dynamic as the plant reconfigures, differing from the commonly assigned value of unity, and for the species’ investigated in this thesis range between 0.95 and 2.92. The newly quantified drag coefficients are used to re-evaluate vegetative flow resistance, and the physically-determined Manning’s n values calculated are highly applicable to conveyance estimators and industry standard hydraulic models used in the management of the river corridor

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome

Impact of ECG findings and process-of-care characteristics on the likelihood of not receiving reperfusion therapy in patients with ST-elevation myocardial infarction: results of a field evaluation.

BACKGROUND: Many patients with ST-elevation myocardial infarction (STEMI) do not receive reperfusion therapy and are known to have poorer outcomes. We aimed to perform the first population-level, integrated analysis of clinical, ECG and hospital characteristics associated with non-receipt of reperfusion therapy in patients with STEMI. METHODS AND RESULTS: This systematic evaluation of STEMI care in 82 hospitals in Quebec included all patients with a discharge diagnosis of myocardial infarction, presenting with characteristic symptoms and an ECG showing STEMI as attested by at least one of two study cardiologists or left bundle branch block (LBBB). Excluding LBBB, an ECG was considered a definite STEMI diagnosis if both cardiologists scored 'certain STEMI' and ambiguous if one scored 'uncertain' or 'not STEMI'. Centers were classified according to accessibility to primary percutaneous coronary intervention (PPCI): 1) on-site PPCI; 2) routine transfer for PPCI; 3) varying mix of PPCI transfer and on-site fibrinolysis; and 4) routine on-site fibrinolysis. Of 3730 STEMI/LBBB patients, 812 (21.8%) did not receive reperfusion therapy. In multivariate analysis, likelihood of no reperfusion therapy was a function of PPCI accessibility (odds ratio [OR] for fibrinolysis versus PPCI centers = 3.1; 95% CI: 2.2-4.4), presence of LBBB (OR = 24.1; 95% CI: 17.8-32.9) and an ECG ambiguous for STEMI (OR = 4.1; 95% CI: 3.3-5.1). When the ECG was ambiguous, likelihood of no reperfusion therapy was highest in hospitals most distant from PPCI centers. CONCLUSIONS: ECG diagnostic ambiguity, LBBB and PPCI accessibility are important predictors of not receiving reperfusion therapy, suggesting opportunities for improving outcomes

Controlled Structure Evolution of Graphene Networks in Polymer Composites

Exploiting graphene’s exceptional physical properties in polymer composites is a significant challenge because of the difficulty in controlling the graphene conformation and dispersion. Reliable processing of graphene polymer composites with uniform and consistent properties can therefore be difficult to achieve. We demonstrate distinctive regimes in morphology and nanocomposite properties, achievable through systematic control of shear rate and shear history. Remarkable changes in electrical impedance unique to composites of graphene nanoplates (GNPs) are observed. Low shear rates ≤ 0.1 s-1 break up the typical GNP agglomerates found in graphene composites, exfoliate the GNPs to fewer graphene layers and reduce orientation, enhancing electrical conductivi-ty in the composite materials. Whereas, at higher shear rates GNP orientation increases and the conductivity reduces by four orders of magnitude, as the graphene filler network is broken down. The structure of the composite continues to evolve, reflected in fur-ther changes in conductivity, after the shear force has been removed and the process temperature maintained. This work provides critical insights for understanding and controlling GNP orientation and dispersion within composites and will have important consequences in the industrial processing of graphene polymer composites via the informed design and choice of processing conditions

Proportion of Patients With Receipt of Reperfusion Therapy (RT) and With Non-Receipt of Reperfusion Therapy (NRT) According to ECG Interpretation and Center Type (N = 3730).

<p>Abbreviations as in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0104874#pone-0104874-t001" target="_blank">Table 1</a>.</p><p>Denominators for percentages in the Table are the number of patients presenting to each type of center with the ECG interpretation in question.</p

Algorithm to identify study patients.

<p>Abbreviations: AMI: acute myocardial infarction. cath lab: cardiac catheterization laboratory. STEMI: ST-segment elevation myocardial infarction. LBBB: left bundle branch block. ECG: electrocardiogram.</p

Univariate Predictors of Non-Receipt of Reperfusion Therapy (N = 3730).

<p>*odds ratio for each 5-year age increment; CI: confidence interval; ECG: electrocardiogram; h: hours; IQR: interquartile range; LBBB: left bundle branch block; MI: myocardial infarction; min: minute; PPCI: primary percutaneous coronary intervention; STEMI: ST-elevation myocardial infarction.</p